Lipids in Health and Disease | |
The relation between serum lipids and lutein and zeaxanthin in the serum and retina: results from cross-sectional, case-control and case study designs | |
关键词: Macular pigment; Lipoproteins; Statins; Lutein; Zeaxanthin; | |
DOI : 10.1186/1476-511X-11-33 | |
来源: DOAJ |
【 摘 要 】
Abstract
Background
The xanthophyll carotenoids lutein (L) and zeaxanthin (Z) are found in and around the macula of the primate retina, where they are termed macular pigment (MP). Dietary L and Z are absorbed with fat in the gut and transported on lipoproteins to the retina. Both MP and serum lipoproteins have been related to risk for neurodegenerative diseases such as age-related macular degeneration (AMD). L and Z are carried on both HDL (related to reduced risk of AMD) and LDL (related to increased risk). The purpose of this set of studies was to analyze the relation between L and Z in the serum and retina with the circulating lipid profile.
Methods
In all experiments, lipoproteins were measured enzymatically from plasma, and MP optical density (MPOD) was measured using customized heterochromatic flicker photometry.
Results
Conclusions
Serum xanthophylls, retinal xanthophylls and lipoprotein concentrations are significantly related, and changing lipoprotein levels may impact levels of retinal xanthophylls.
【 授权许可】
Unknown