Proton magnetic resonance spectroscopy and apparent diffusion coefficient in evaluation of solid brain lesions

Vojnosanitetski Pregled

关键词: brain neoplasms;    glioma;    brain ischemia;    diagnosis;    diagostic techniques and procedures;    magnetic resonance imaging;    magnetic resonance spectroscopy;   

DOI  :  10.2298/VSP110223044R

来源: DOAJ

【 摘 要 】

Background/Aim. Advanced magnetic resonance techniques can provide insight inphysiological changes within pathological canges and contribute to betterdistinquishing between different tumor types and their discrimination fromnon-neoplastic lesions. The aim of this study was to evaluate the role ofproton magnetic resonance spectroscopy (1H-MRS) and apparent diffusioncoefficients (ADC) in distinguishing intracranial glial tumors from tumorlike nonneoplastic lesions, as well as for differentiating high- fromlow-grade gliomas. Methods. This retrospective study included 47 patientswith solid brain lesions (25 nonneoplastic, 14 low-grade and 8 anaplasticglial tumors). In all patients 1H-MRS (at a TE of 135 ms and 30 ms) anddiffusion- weighted imaging (DWI) were performed. The choline to creatine(Cho/Cr), choline to N-acetyl aspartate (Cho/NAA), N-acetyl aspartate tocreatine (NAA/Cr) and myoinositol to creatine (mIn/Cr) ratios and theapparent diffusion coefficient (ADC) were determined. Results. The Cho/Crratio was significantly higher in glial tumors grade II than innon-neoplastic lesions (p = 0.008) and in glial tumors grade III than innon-neoplastic lesions (p = 0.001). The Cho/NAA ratio was significantlyhigher in glial tumors grade II than in non-neoplastic lesions (p = 0.037).ΔADC/ADC between glial tumors grade II and glial tumors grade III showed astatistical significance (p = 0.023). Conclusion. Our study showed that1H-MRS and apparent diffusion coefficients can help in evaluation anddifferentiation of solid brain lesions.

【 授权许可】

Unknown