Effective Treatment of Cervical Lymph Node Metastasis of Breast Cancer by Low Voltage High-Frequency Electrochemotherapy

Acta Medica Iranica

Kambiz Novin¹  Bahram Mofid²  Morteza Shankayi³  S. Mohammad Firoozabadi⁴  Zeinab Shankayi⁴  Sadegh Dehghani⁵  Hamidreza Haghighatkhah⁶ 

[1] Department of Clinical Oncology, Imam Hossein Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.;Department of Clinical Oncology, Shohada-e-Tajrish Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.;Department of Mechanic, School of Engineering, Tarbiat Modares University, Tehran, Iran.;Department of Medical Physics, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran.;Department of Medical Physics, Tehran University of Medical Sciences, Tehran, Iran.;Department of Radiology, Shohada-e-Tajrish Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.;

关键词: Low voltage;    High frequency;    Electrochemotherapy;    Bleomycin;    Lymphadenopathy;   

DOI  :  

来源: DOAJ

【 摘 要 】

Electrochemotherapy (ECT) is a new local treatment method for solid and superficial tumors. During this new technique, patients experience an unpleasant sensation and slight edema. Most unpleasant and painful is mainly attributed to muscle contractions provoked by high amplitude and low repetition frequency pulses. Recently, we showed that electrochemotherapy using low voltage and higher repetition frequency (LVHF ECT) is an effective tool for inhibiting tumor growth and inducing cell permeabilization. Low voltage high-frequency electrochemotherapy was developed and optimized in vitro and in vivo which and can be used in the clinic. In the present study, we report a case of cervical lymph node metastasis of breast cancer treated by the technique. In our case, LVHF ECT was successful in reducing the size and palliating the symptoms of cervical lymph node metastasis in clinical conditions, whereas other approaches were inefficient. Our electrochemotherapy technique shows good clinical results. However, more studies on this new method are necessary to prove that LVHF ECT can be considered as a standard treatment modality.

【 授权许可】

Unknown