Functions and therapeutic roles of exosomes in cancer

Frontiers in Oncology

Sally-Anne eStephenson¹  Jacob Andrew Tickner¹  Kenneth John O'Byrne¹  Derek John Richard¹  Aaron James Urquhart¹ 

[1] Translational Research Institute;

关键词: Cancer;    exosome;    metastatic niche;    chemotherapeutic resistance;    biomarker.;   

DOI  :  10.3389/fonc.2014.00127

来源: DOAJ

【 摘 要 】

The role of exosomes in cancer development has become the focus of much research, due to the many emerging roles possessed by these microscopic messengers. Exosomes are ubiquitously released in to the extracellular milieu, and have been found to regulate immune system function, particularly in tumorigenesis, as well as conditioning future metastatic sites for the attachment and growth of tumor tissue. Through an interaction with a range of host tissues, exosomes are able to generate a pro-tumor environment that is essential for carcinogenesis. Herein, we discuss the contents of exosomes and their contribution to tumorigenesis, as well as their role in chemotherapeutic resistance and the development of novel cancer treatments and the identification of cancer biomarkers.

【 授权许可】

Unknown