Molecular Basis of Lung Tropism of Metastasis

Cancer Genomics - Proteomics

FABIAN BIRZELE¹  GWENDLYN KOLLMORGEN¹  ULRICH H. WEIDLE¹  RÜDIGER RÜGER⇑¹ 

[1] Roche Pharma Research and Early Development, Roche Innovation Center Penzberg, Roche Diagnostics GmbH, Penzberg, GermanyRoche Pharma Research and Early Development, Roche Innovation Center Penzberg, Roche Diagnostics GmbH, Penzberg, GermanyRoche Pharma Research and Early Development, Roche Innovation Center Penzberg, Roche Diagnostics GmbH, Penzberg, Germany

关键词: Lung metastasis and colonization;    lung metastasis signature;    metastatic niche;    tumor cell–stromal cell interaction;    review;   

DOI  :  

来源: Delinasios GJ CO

【 摘 要 】

A predilection of metastasis to the lungs has been noted for several types of cancer. Herein, we summarize underlying mechanisms for lung tropism of metastasis. We discuss the identification of a gene signature in primary breast tumors predicting metastasis to the lungs, as well as functional validation of selected genes of the signature. We outline the contribution of pre- and metastatic niches, the role of exosomes, activation of disseminated, dormant tumor cells and selected tumor–stromal cell interactions to lung metastasis and colonization. We also refer to metastasis-mediating mechanisms based on alterations of the tumor cell cytoskeleton, as well as lung metastasis-suppressing mechanisms.

【 授权许可】

Unknown