A microporous roust La(III)-organic framework for cyanosilylation reactions and treatment effect on tuberculosis by activating the PI3K-AKT signaling pathway in immune cells

Arabian Journal of Chemistry

Qin Sun¹  Zhibin Liu¹  Min Wu¹  Liping Yan¹  Li Liang¹  Qing Zhang² 

[1]Clinic and Research Center of Tuberculosis, Shanghai Key Laboratory of Tuberculosis, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China

[2]Correspondng author.

关键词: La(III)-framework;    Porous structure;    Cyanosilylation of benzaldehyde;    Tuberculosis;   

DOI  :  

来源: DOAJ

【 摘 要 】

A novel metal–organic framework (MOF) based on La(III) ions as the metal nodes with the formula of {[LaL(H2O)2]·H2O}n (1) was prepared under the hydrothermal conditions by using 1-(4-carboxybenzyl)-1H-pyrazole-3,5-dicarboxylic acid (H3L) as the three connected ligand. Complex 1 shows excellent water stabilities as well as solvent-free conditions, and reveals microporous nature as established via the CO2 sorption at 195 K. The resulting activated 1a shows good heterogeneous catalytic activity for the cyanosilylation of the aromatic aldehydes, which could be reused for at least four times without losing the framework integrality. Furthermore, anti-bacterial activity of the compound was deep studied within the research. Firstly, the RT-PCR was utilized to determine pi3k and akt relative expression in macrophages after tuberculosis (TB) infection and compound treatment. And the ELISA detection was enrolled for IFN-γ and TNF-α detection. Next, the production of active nitrogen mediator (RNIs) was measured by the RNIs detection kit. Finally, compound protective function in vivo was assessed within the TB infected mice model, the bacterial colony numbers in the lung tissue was determined by diluting ager plate method, the pathological injury of lung was observed by HE staining. In this research, we aim to reveal a new candidate for the TB infection treatment.

【 授权许可】

Unknown