Phytochemical Compositions and Biological Activities of Essential Oils from the Leaves, Rhizomes and Whole Plant of Hornstedtia bella Škorničk

Antibiotics

Giuseppina Sanna¹  Silvia Madeddu¹  Nicia Diaz²  Piero Cappuccinelli²  Paola Molicotti²  Paola Rappelli²  MatthewGavino Donadu²  Stefania Zanetti²  Donatella Usai²  Marianna Usai³  Antonio Carta³  Sandra Piras³  Duc Viet Ho⁴  Nhan Trong Le⁴  Tuan Quoc Doan⁴  Hoai Thi Nguyen⁴  Mauro Marchetti⁵  Ain Raal⁶  Anh Tuan Le⁷ 

[1] Department of Biomedical Sciences, University of Cagliari, 09042 Monserrato, Italy;Department of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy;Department of Chemistry and Pharmacy, University of Sassari, 07100 Sassari, Italy;Faculty of Pharmacy, Hue University of Medicine and Pharmacy, Hue University, Hue 49000, Vietnam;Institute of Biomolecular Chemistry (CNR), Li Punti, 07100 Sassari, Italy;Institute of Pharmacy, Faculty of Medicine, University of Tartu, 50900 Tartu, Estonia;Mientrung Institute for Scientific Research, VAST, Hue 49000, Vietnam;

关键词: essential oils;    infections;    antifungal activity;    antimicrobial activity;   

DOI  :  10.3390/antibiotics9060334

来源: DOAJ

【 摘 要 】

The rapid emergence of drug-resistant strains and novel viruses have motivated the search for new anti-infectious agents. In this study, the chemical compositions and cytotoxicity, as well as the antibacterial, antifungal, antitrichomonas, and antiviral activities of essential oils from the leaves, rhizomes, and whole plant of Hornstedtia bella were investigated. The GC/MS analysis showed that β-pinene, E-β-caryophyllene, and α-humulene were found at high concentrations in the essential oils. The essential oils exhibited (i) inhibition against Staphylococcus aureus, methicillin-resistant Staphylococcus aureus, Staphylococcus epidermidis with minimum inhibitory concentrations (MIC) and minimum lethal concentration (MLC) values from 1 to 4% (v/v); (ii) MIC and MLC values from 2 to 16% (v/v) in Candida tropicalis and Candida parapsilosis; (iii) MIC and MLC values from 4 to 16% in Enterococcus faecalis; and (iv) MIC and MLC values from 8 to greater than or equal to 16% (v/v) in the remaining strains, including Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, Candida albicans, and Candida glabrata. In antitrichomonas activity, the leaves and whole-plant oils of Hornstedtia bella possessed IC₅₀, IC₉₀, and MLC values of 0.008%, 0.016%, and 0.03% (v/v), respectively, whilst those of rhizomes oil had in turn, 0.004%, 0.008%, and 0.016% (v/v).Besides, the leaf oil showed a weak cytotoxicity against Vero 76 and MRC-5; meanwhile, rhizomes and whole-plant oils did not exert any toxic effects on cell monolayers. Finally, these oils were not active against EV-A71.

【 授权许可】

Unknown