Adverse effects of chemoradiotherapy on invasion and metastasis of tumor cells

Genes and Diseases

Zhao-You Tang¹  Yong Liao²  Wen-Hui Li³  Wei Xiong³  Ji-Yong Qin³ 

[1] Corresponding author. The Department of Radiation Oncology, Yunnan Cancer Hospital, The Third Affiliated Hospital of Kunming Medical University, Kunming, 650106, China. Fax: [phone].;Institute for Viral Hepatitis, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China;The Department of Radiation Oncology, Yunnan Cancer Hospital, The Third Affiliated Hospital of Kunming Medical University, Kunming, China;

关键词: Biological behavior;    Cancer;    Chemoradiotherapy;    Mechanism;    Invasion and metastasis;   

DOI  :  

来源: DOAJ

【 摘 要 】

The phenomenon of enhanced invasion and metastasis of residual tumor cells has been observed in an increasing number of patients receiving chemoradiotherapy recently, and tumor metastasis will undoubtedly limit patient prognosis. However, the key mechanism by which chemoradiotherapy affects the invasion and metastasis of tumor cells remains unclear. Studies have shown that chemoradiotherapy may directly act on tumor cells and alter the tumor microenvironment, or induce cell apoptosis and autophagy to promote tumor cell survival and metastasis. In this review, we summarize the potential mechanisms by which chemoradiotherapy may affect the biological behavior of tumor cells and open up new avenues for reducing tumor recurrence and metastasis after treatment. These insights will improve the efficacy of chemoradiotherapy.

【 授权许可】

Unknown