Molecular and Immunohistochemical Markers with Prognostic and Predictive Significance in Liver Metastases from Colorectal Carcinoma

International Journal of Molecular Sciences

Gianluca Lopez¹  Alessandro Del Gobbo¹  Nicola Fusco¹  Francesca Boggio¹  Stefano Ferrero¹ 

[1] Division of Pathology, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, via Francesco Sforza 35, 20122 Milan, Italy;

关键词: biomarkers;    immunohistochemistry;    molecular markers;    colorectal cancer;    liver metastases;    prognostic;    predictive;   

DOI  :  10.3390/ijms19103014

来源: DOAJ

【 摘 要 】

Despite the significant recent achievements in the diagnosis and treatment of colorectal cancer (CRC), the prognosis of these patients has currently plateaued. During the past few years, the opportunity to consider multiple treatment modalities (including surgery and other locoregional treatments, systemic therapy, and targeted therapy) led to the research of novel prognostic and predictive biomarkers in CRC liver metastases (CRCLM) patients. In this review, we seek to describe the current state of knowledge of CRCLM biomarkers and to outline impending clinical perspectives, in particular focusing on the cutting-edge tools available for their characterization.

【 授权许可】

Unknown