The Regenerative Potential of Substance P

International Journal of Molecular Sciences

Patrycja Redkiewicz¹ 

[1] Department of Neuropeptides, Mossakowski Medical Research Institute Polish Academy of Sciences, 5 Pawińskiego Street, PL 02-106 Warsaw, Poland;

关键词: substance P;    wound healing;    chronic wounds;    acute wounds;    animal wound model;    diabetes;   

DOI  :  10.3390/ijms23020750

来源: DOAJ

【 摘 要 】

Wound healing is a highly coordinated process which leads to the repair and regeneration of damaged tissue. Still, numerous diseases such as diabetes, venous insufficiencies or autoimmune diseases could disturb proper wound healing and lead to chronic and non-healing wounds, which are still a great challenge for medicine. For many years, research has been carried out on finding new therapeutics which improve the healing of chronic wounds. One of the most extensively studied active substances that has been widely tested in the treatment of different types of wounds was Substance P (SP). SP is one of the main neuropeptides released by nervous fibers in responses to injury. This review provides a thorough overview of the application of SP in different types of wound models and assesses its efficacy in wound healing.

【 授权许可】

Unknown