Sorafenib, a systemic therapy for hepatocellular carcinoma

Annals of Hepatology

Francisco Vásquez-Fernández¹  Misael Uribe²  Daniel Zamora-Valdés²  Nahum Méndez-Sánchez^{3  3} 

[1] Address for correspondence:;Foundation, Mexico City, Mexico;;Liver Unit, Medica Sur Clinic &

关键词: Liver cancer;    hepatocellular carcinoma;    HCV;    HBV;    sorafenib;   

DOI  :  

来源: DOAJ

【 摘 要 】

Hepatocellular carcinoma is a lethal disease that requires a multidisciplinary approach and management. Surgical therapy offers long-term survival; however, few patients are candidates. There has been no accepted systemic therapy for this disease until recently. This article briefly discusses the role of RAS/RAF/MEK/ ERK signaling pathway in the pathogenesis of the disease and the promising role of sorafenib for advanced disease.

【 授权许可】

Unknown