Cooperative repression of cyclin‐dependent kinase inhibitor p21 gene expression by hepatitis B virus X protein and hepatitis C virus core protein

FEBS Letters

Lee, Woo Jung¹  Jung, Eun Young¹  Han, Hae Jin¹  Jang, Kyung Lib¹ 

[1] Department of Microbiology, College of Natural Sciences, Pusan National University, Pusan 609-735, South Korea

关键词: Core;    Hepatitis B virus;    Hepatitis B virus X protein;    Hepatocellular carcinoma;    Hepatitis C virus;    p21;    CDK;    cyclin-dependent kinase;    HBV;    hepatitis B virus;    HBx;    hepatitis B virus X protein;    HCV;    hepatitis C virus;    HCC;    hepatocellular carcinoma;    TβRE;    transforming growth factor-β responsive element;   

DOI  :  10.1016/S0014-5793(02)02694-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Co-infection with hepatitis B virus (HBV) and hepatitis C virus (HCV) is common and is associated with a more severe liver disease and increased frequency in the development of hepatocellular carcinoma (HCC). Here, we demonstrated that HBV X protein (HBx) and HCV core protein additively repress the universal cyclin-dependent kinase inhibitor p21 gene at the transcription level. The transforming growth factor-β responsive element and Sp1 site of the p21 promoter were responsible for the effect of HCV core and HBx, respectively. Furthermore, cell growth was additively stimulated by them, suggesting that additive repression of the p21 might be important to understand the cooperative development of HCC by HBV and HCV.

【 授权许可】

Unknown