Review on Inflammation Markers in Chronic Kidney Disease

Biomedicines

Robert Ekart¹  Nejc Piko²  Sebastjan Bevc²  Radovan Hojs²  Tadej Petreski² 

[1] Department of Internal Medicine and Department of Pharmacology, Faculty of Medicine, University of Maribor, Taborska Ulica 8, 2000 Maribor, Slovenia;Department of Nephrology, Clinic for Internal Medicine, University Medical Centre Maribor, Ljubljanska ulica 5, 2000 Maribor, Slovenia;

关键词: inflammation markers;    chronic kidney disease;    cytokines;    chemokines;    cell adhesion molecules;   

DOI  :  10.3390/biomedicines9020182

来源: DOAJ

【 摘 要 】

Chronic kidney disease (CKD) is one of the major health problems of the modern age. It represents an important public health challenge with an ever-lasting rising prevalence, which reached almost 700 million by the year 2017. Therefore, it is very important to identify patients at risk for CKD development and discover risk factors that cause the progression of the disease. Several studies have tackled this conundrum in recent years, novel markers have been identified, and new insights into the pathogenesis of CKD have been gained. This review summarizes the evidence on markers of inflammation and their role in the development and progression of CKD. It will focus primarily on cytokines, chemokines, and cell adhesion molecules. Nevertheless, further large, multicenter studies are needed to establish the role of these markers and confirm possible treatment options in everyday clinical practice.

【 授权许可】

Unknown