Systemic Oxidative Stress Is Increased in Postmenopausal Women and Independently Associates with Homocysteine Levels

International Journal of Molecular Sciences

SanneJ. Gordijn¹  Khamis Al-Hashmi¹  MarianL. C. Bulthuis¹  MarvinB. Enriquez¹  Muna Al-Maqbali¹  Jumana Saleh¹  Sultan Al-Siyabi²  AreejM. Al-Rawas²  Mohsin Al-Saleh²  ArnoR. Bourgonje³  Intisar Al-Lawati⁴  Harry van Goor⁵  DouweJ. Mulder⁵  AmaalEman Abdulle⁶ 

[1] Health Sciences, Sultan Qaboos University, P.O. Box 35, Al-Khoud 123, Muscat, Oman;;Department of Biochemistry, College of Medicine &Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands;;Department of Microbiology and Immunology, College of Medicine &;Department of Physiology, College of Medicine &Division of Vascular Medicine, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands;

关键词: oxidative stress;    postmenopausal women;    menopause;    free thiols;    homocysteine;    cardiovascular disease;    obesity;    risk factors;   

DOI  :  10.3390/ijms21010314

来源: DOAJ

【 摘 要 】

Oxidative stress plays a pivotal role in the pathogenesis of cardiovascular diseases (CVD). Postmenopausal women have an increased risk of developing CVD due to decreased estrogen availability, which is accompanied by increased oxidative stress. Serum free thiols (R-SH) provide a robust and powerful read-out of systemic oxidative stress. In this study, we aimed to establish serum levels of free thiols and explore associations between free thiols and demographic, clinical, and biochemical parameters related to obesity and the risk for developing CVD in both pre- and postmenopausal women. Serum free thiols were measured in a cohort consisting of healthy pre- (n = 223) and postmenopausal (n = 118) Omani women. Postmenopausal women had significantly lower levels of serum free thiols as compared to premenopausal women (762.9 ± 85.3 vs. 780 ± 80.9 μM, age-adjusted p < 0.001). Women′s age was positively associated with serum free thiol levels in premenopausal women (β = 0.36, p = 0.002), whereas an inverse association was observed in postmenopausal women (β = −0.29, p = 0.002). Homocysteine levels were significantly inversely associated with serum free thiol levels in both pre- (β = −0.19, p = 0.005) and postmenopausal (β = −0.20, p = 0.032) women, independent from known cardiovascular risk factors. In this study, we show that postmenopausal women are affected by increased systemic oxidative stress, which independently associates with homocysteine levels.

【 授权许可】

Unknown