Systemic Oxidative Stress, Aging and the Risk of Cardiovascular Events in the General Female Population

Frontiers in Cardiovascular Medicine

article

Martin F. Bourgonje¹  Arno R. Bourgonje²  Amaal E. Abdulle³  Lyanne M. Kieneker⁴  Sacha la Bastide-van Gemert⁵  Ron T. Gansevoort⁴  Stephan J. L. Bakker⁴  Douwe J. Mulder³  Andreas Pasch⁶  Jumana Saleh⁷  Sanne J. Gordijn⁸  Harry van Goor¹ 

[1] Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen;Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen;Division of Vascular Medicine, Department of Internal Medicine, University Medical Center Groningen, University of Groningen;Division of Nephrology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen;Department of Epidemiology, University Medical Center Groningen, University of Groningen;Department of Physiology and Pathophysiology, Institute for Physiology and Pathophysiology, Johannes Kepler University Linz;Department of Biochemistry, College of Medicine & Health Sciences, Sultan Qaboos University;Department of Obstetrics and Gynecology, University Medical Center Groningen, University of Groningen

关键词: menopause;    oxidative stress;    free thiols;    cardiovascular events;    population study;   

DOI  :  10.3389/fcvm.2021.630543

学科分类：地球科学(综合)

来源: Frontiers

【 摘 要 】

Introduction: Menopause is associated with increased cardiovascular risk, in which oxidative stress plays a pivotal role. Systemic oxidative stress is reflected by decreased levels of free thiols (R-SH, sulfhydryl groups), which are key components of the extracellular antioxidant machinery. In this study, we investigated the relation between serum free thiols as marker of oxidative stress and the female cardiovascular phenotype, as well as potential associations with the risk of cardiovascular (CV) events in pre- and postmenopausal women from the general population. Methods: Female participants ( n = 2,980) of the Prevention of REnal and Vascular ENd-stage Disease (PREVEND) cohort study were included. Serum free thiol concentrations were analyzed for associations with demographic, clinical, biochemical, and gynecological parameters, as well as with menopausal status and, prospectively, with the risk of CV events. Results: Postmenopausal women had significantly reduced levels of serum free thiols (4.8 ± 1.0 vs. 5.2 ± 1.0 μmol/g, P < 0.001) compared to reproductive women. In multivariable analyses, serum free thiols were significantly associated with menopausal status (OR 0.70 [0.49–0.98], P = 0.039), even when adjusted for potential confounding factors, except for age ( P = 0.550). Prospectively, serum free thiols were significantly associated with the risk of CV events (HR 0.52 [0.27–0.97], P = 0.040), even with covariate adjustment, although this disappeared when correcting for age. Conclusion: In this study, we revealed serum free thiols to be strongly associated with the female cardiovascular phenotype as well as with female risk of CV events, where the influence of age itself seemed to outweigh that of female menopause. Future studies are warranted to further unravel the clinical utility of serum free thiol levels in the context of female cardiovascular risk management.

【 授权许可】

CC BY