Sexual maturation and fertility of mice exposed to triphenyltin during prepubertal and pubertal periods

Toxicology Reports

Isabella F. Delgado¹  Camila M.T. Lopes¹  Wilma De-Grava Kempinas²  Ana Paula A. Favareto²  Francisco J.R. Paumgartten³  Marcia S. Campos Mello³  Marcelo M. Batista⁴ 

[1] Department of Immunology, National Institute of Health Quality Control, Brazil;Department of Morphology, State University of São Paulo (UNESP), Botucatu, São Paulo, Brazil;Laboratory of Environmental Toxicology, Department of Biological Sciences, National School of Public Health, Brazil;Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, RJ 21045-900, Brazil;

关键词: Triphenyltin;    TPTH;    Organotin compounds;    Puberty;    Postnatal exposure;    Fertility;   

DOI  :  10.1016/j.toxrep.2014.12.006

来源: DOAJ

【 摘 要 】

This study investigated the effects of pre- and peripubertal exposure (PND 15–45) to triphenyltin hydroxide (TPT: 0, 1.875, 3.75, 7.5 and 15 mg/kg bw/d po) on mouse sexual maturation and fertility. Half of the mice were euthanized on PND 46 and the remaining mice were submitted to fertility tests on PND 65–75. TPT caused a transient decrease of weight gain at 3.75 mg/kg bw/d, and deaths and body weight deficits at higher doses. Delays of testes descent (TD), vaginal opening (VO) and first estrus (FE) occurred at doses ≥3.75 (TD) and ≥7.5 mg/kg bw/d (VO, FE), respectively. Body weight on the days of TD, VO and FE did not differ among groups. TPT at doses ≥3.75 mg/kg decreased sperm and spermatid counts at the end of treatment (PND 46) but no alteration was noted later on PND 75. Testicular histopathology (PND 46) showed a dose-dependent reduction of seminiferous tubules diameter, a greater degree of vacuolation in Sertoli cells and germ cell degeneration and necrosis in TPT-treated mice. TPT did not affect the outcome of fertility tests. Study-derived NOAEL was 1.875 mg TPT/kg bw/d for males and 3.75 mg TPT/kg bw/d for females. The detrimental effects of TPT on spermatogenesis were reversed after treatment discontinuation.

【 授权许可】

Unknown