Tumor‐specific and photothermal‐augmented chemodynamic therapy by ferrocene‐carbon dot‐crosslinked nanoparticles

SmartMat

Zhongjun Li¹  Yike Li¹  Yao Yu²  Qiao Chen³  Shan Sun⁴  Hengwei Lin⁴ 

[1] College of Chemistry and Molecular Engineering Zhengzhou University Zhengzhou China;Department of Cardiovascular Thoracic Surgery Tianjin Medical University General Hospital Tianjin China;Mechanobiology and Regenerative Medicine Laboratory, Bioengineering College Chongqing University Chongqing China;School of Chemical and Material Engineering, International Joint Research Center for Photo‐responsive Molecules and Materials Jiangnan University Wuxi China;

关键词: carbon dots;    crosslinked nanoparticles;    ferrocene;    synergistic therapy;    tumor specificity;   

DOI  :  10.1002/smm2.1119

来源: DOAJ

【 摘 要 】

Abstract Extensive research have been devoted to the exploration of multifunctional theranostic agents for cancer, but the poor tumor specificity and unsatisfactory treatment efficacy are some of the critical obstacles for their clinical translations. Herein, ferrocene‐carbon dot‐crosslinked nanoparticles (Fc‐CD NPs) were designed and fabricated for achieving highly specific and photothermal‐augmented chemodynamic therapy (CDT). The Fc‐CD NPs were found not only to inherit the immanent fluorescence, photoacoustic, and photothermal properties of carbon dots (CDs), but also be endowed with CDT that could occur selectively in tumor microenvironment (TME) due to the presence of Fc for triggering Fenton reaction. Moreover, the enlarged particle size of Fc‐CD NPs facilitated their effective accumulation at tumor sites, thus realizing great improvement for antitumor treatment outcomes. Once docking at tumor and being exposed to 660 nm laser irradiation, significantly amplified CDT effect of Fc‐CD NPs was observed due to heat‐accelerating generation of reactive oxygen species (ROS). More interestingly, since the produced ROS could in turn alleviate the thermal‐resistance of photothermal therapy (PTT), the therapeutic efficiency of integrated PTT and CDT was synergized to the maximum extent. This study on the one hand provides a facile approach to fabricate CDs‐based multifunctional theranostic nanoplatform with enhanced tumor accumulation and specificity, on the other hand emphasizes the merits of synergizing mutually beneficial therapeutic modalities for more efficient cancer therapy.

【 授权许可】

Unknown