The first efficient biocatalytic route for the synthesis of Kojic acid derivatives in aqueous media

Catalysis Communications

Bhushan L. Chaudhari¹  Dipak S. Dalal²  Kiran S. Dalal³  Mangal A. Chaudhari³ 

[1] Corresponding authors.;School of Chemical Sciences, Kavayitri Bahinabai Chaudhari North Maharashtra University, Jalgaon 425 001, Maharashtra, India;School of Life Sciences, Kavayitri Bahinabai Chaudhari North Maharashtra University, Jalgaon 425 001, Maharashtra, India;

关键词: Aspergillus niger;    Lipase;    Biocatalysis;    Kojic acid derivatives;   

DOI  :  

来源: DOAJ

【 摘 要 】

The first efficient biocatalytic route for the synthesis of kojic acid derivatives was developed in presence of an enzyme. In this process, benzaldehydes, malononitrile and kojic acid were used as starting materials while lipase from Aspergillus niger was the promiscuous biocatalyst giving high conversion (82–95%) of kojic acid derivatives in aqueous medium. The probable enzymatic mechanism is proposed here. The lipase was reused till three consecutive cycles without a significant loss of activity. This efficient bioprocess has potential to replace the existing chemical catalytic processes to produce heterocyclic anti-tyrosinase compounds that prevents hyperpigmentation.

【 授权许可】

Unknown