Biomechanical Properties of 3D-Printed Cervical Interbody Fusion Cage With Novel SF/nHAp Composites

Frontiers in Materials

Dongfang Yang¹  Guozhi Wu¹  Hao Zhang¹  Jianyu Hu¹  Zhize Liu¹  Xiaodong Lian¹  Shuang Chen¹  Guiqi Zhang¹  Yi Meng¹  Kun Li² 

[1] Department of Orthopedics, Affiliated Dalian Municipal Central Hospital, Dalian Medical University, Dalian, China;Department of Orthopedics, The Peoples Hospital of Langfang City, Langfang, China;

关键词: 3D printing;    cervical interbody fusion cages;    biomechanical properties;    silk fibroin;    nano-hydroxyapatite;    composites;   

DOI  :  10.3389/fmats.2021.719536

来源: DOAJ

【 摘 要 】

Anterior cervical discectomy and fusion (ACDF) is a commonly used surgical method for the treatment of cervical spondylosis. As ACDF surgery is widely used in clinics, identifying suitable materials to design and prepare cervical interbody fusion cages is a hot research topic. Here, we describe a new three-dimensional (3D) printing approach to create stretchable and tough silk fibroin/nano-hydroxyapatite (SF/nHAp) composites with tunable mechanical properties. The compressive strength of the novel composites with biomimetic structure could reach more than 128 MPa. More importantly, the composites were prepared using 30% silk fibroin and 70% hydroxyapatite, a composition similar to the human bone tissue. Finite element analysis results indicate that the stress distribution of SF/nHAp composite cervical interbody fusion cages in vivo is more uniform than that of commercial Ti alloy cages. This study evaluates the effectiveness of SF/nHAp composites for application in cervical interbody fusion cages and in the field of bone tissue engineering.

【 授权许可】

Unknown