Long Non-coding RNA AK025387 Promotes Cell Migration and Invasion of Gastric Cancer

Frontiers in Oncology

Hui Zhang²  Peng Gao²  Ya-Ru Tian²  Ran-Ran Ma²  Guo-Hao Zhang²  Lin Liu²  Lei Liu²  Yi-Yuan Sun² 

[1] Department of Pathology, Qilu Hospital, Shandong University, Jinan, China;Key Laboratory for Experimental Teratology of the Ministry of Education, Department of Pathology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, China;

关键词: long non-coding RNA;    gastric cancer;    AK025387;    migration and invasion;    MAPK signaling pathway;   

DOI  :  10.3389/fonc.2020.00633

来源: DOAJ

【 摘 要 】

Gastric cancer is one of the most common cancers in the world, and long non-coding RNAs (lncRNAs) play a crucial role in proliferation, metastasis, and invasion of gastric cancer. However, there are very few researches focusing on the effects of lncRNAs on metastatic gastric cancer. In this research, we identify one kind of lncRNA, called AK025387, which is highly expressed in metastatic gastric cancer samples compared with non-metastatic gastric cancer samples. The expression of AK025387 is significantly positively correlated with lymph node metastasis. The in situ hybridization demonstrates that AK025387 is located in both nucleus and cytoplasm, but mostly in cytoplasm. AK025387 promotes gastric cancer cells migratory and invasive ability, but it inhibits apoptosis in vitro. Furthermore, AK025387 regulates Raf-1, mitogen-activated protein kinase/extracellular signal-regulated kinase (MEK), and extracellular signal-regulated kinase (ERK) and is involved in mitogen-activated protein kinase (MAPK) signaling pathway to perform its biological functions. We conclude that AK025387 is highly expressed in metastatic gastric cancer, and its biological functions suggest the potential of AK025387 to be a biomarker of metastatic gastric cancer.

【 授权许可】

Unknown