Hematopoietic pre‐B cell leukemia transcription factor interacting protein is overexpressed in gastric cancer and promotes gastric cancer cell proliferation, migration, and invasion

Cancer Science

Yingying Feng³  Ling Li³  Xiaomei Zhang²  Yunjing Zhang¹  Yingchun Liang³  Jinjing Lv³  Zhongyi Fan³  Jing Guo³  Tian Hong³  Beibei Ji³  Quanbo Ji³  Guohui Mei³  Lihua Ding³  Shu Zhang⁴  Xiaojie Xu³ 

[1] Department of Colorectal Surgery, the Second Artillery General Hospital, Beijing, China;Department of Gastroenterology and Hepatology, Chinese PLA General Hospital, Beijing, China;Department of Medical Molecular Biology, Beijing Institute of Biotechnology, Beijing, China;Department of Gastrointestinal Oncology, Shandong Cancer Hospital and Institute, Jinan, China

关键词: Cell growth;    EMT;    gastric cancer;    HPIP;    migration and invasion;   

DOI  :  10.1111/cas.12754

来源: Wiley

【 摘 要 】

Abstract

Hematopoietic pre-B cell leukemia transcription factor interacting protein (HPIP) has been shown to play an important role in the development and progression of some cancers. However, the role of HPIP in gastric cancer (GC) is unclear. Here, we show that HPIP is upregulated in most GC patients and promotes GC cell proliferation, migration, and invasion. In GC patients, HPIP positively associates with tumor size and nodal metastasis, and negatively associates with tumor differentiation. Hematopoietic pre-B cell leukemia transcription factor interacting protein increases GC cell proliferation through activation of G₁/S and G₂/M cell cycle transitions, accompanied by a marked increase of the positive cell cycle regulators, including cyclin D1, cyclin A, and cyclin B1. Hematopoietic pre-B cell leukemia transcription factor interacting protein enhances GC cell migration and invasion, and modulates epithelial–mesenchymal transition, which plays a key role in cancer cell migration and invasion. These data underscore the critical role of HPIP in GC cell proliferation and progression and suggest that HPIP inhibition may be a useful therapeutic strategy for GC treatment.

【 授权许可】

CC BY-NC-ND   
© 2015 The Authors. Cancer Science published by Wiley Publishing Asia Pty Ltd on behalf of Japanese Cancer Association.

Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.