Functional Biomaterials for Treatment of Chronic Wound

Frontiers in Bioengineering and Biotechnology

Wentao Shu¹  Xi Zhang²  Qinghua Yu²  Wenrui Qu³  Rui Li³  Yinan Wang⁴ 

[1] Department of Biobank, Division of Clinical Research, The First Hospital of Jilin University, Changchun, China;Department of Burn Surgery, The First Hospital of Jilin University, Changchun, China;Department of Hand Surgery, The Second Hospital of Jilin University, Changchun, China;Key Laboratory of Organ Regeneration and Transplantation, The First Hospital of Jilin University, Changchun, China;

关键词: chronic wound;    functional biomaterials;    immunoregulation;    antioxidant;    angiogenesis;   

DOI  :  10.3389/fbioe.2020.00516

来源: DOAJ

【 摘 要 】

The increasing number of patients with chronic wounds caused by diseases, such as diabetes, malignant tumors, infections, and vasculopathy, has caused severe economic and social burdens. The main clinical treatments for chronic wounds include the systemic use of antibiotics, changing dressings frequently, operative debridement, and flap repair. These routine therapeutic strategies are characterized by a long course of treatment, substantial trauma, and high costs, and fail to produce satisfactory results. Biomaterial dressings targeting the different stages of the pathophysiology of chronic wounds have become an active research topic in recent years. In this review, after providing an overview of the epidemiology of chronic wounds, and the pathophysiological characteristics of chronic wounds, we highlight the functional biomaterials that can enhance chronic wound healing through debridement, anti-infection and antioxidant effects, immunoregulation, angiogenesis, and extracellular matrix remodeling. It is hoped that functional biomaterials will resolve the treatment dilemma for chronic wounds and improve patient quality of life.

【 授权许可】

Unknown