Multifunctional Injectable Hydrogel Loaded with Cerium-Containing Bioactive Glass Nanoparticles for Diabetic Wound Healing

Biomolecules

Zhou-Feng Rao¹  Lin Zhang¹  Chun-Xiao Qi¹  Xiang-Sheng Liu¹  Ze-Qi Wang¹  Jing-Yue Guo¹  Yu-Fei Liu¹  Yun-Sheng Dong¹  Shu-Fang Wang¹  Yue-Hua Chen¹  Lan-Ju Xu²  Yu-Jie Liu³  Chao Yang³ 

[1] Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences, Nankai University, Tianjin 300071, China;Key Laboratory of Bioactive Materials, Ministry of Education, College of Medicine Sciences, Nankai University, Tianjin 300071, China;Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, College of Life Sciences, Nankai University, Tianjin 300071, China;

关键词: diabetic foot ulcers;    bioactive glass;    cerium;    hydrogel;    angiogenesis;   

DOI  :  10.3390/biom11050702

来源: DOAJ

【 摘 要 】

Diabetic foot wound healing is a major clinical problem due to impaired angiogenesis and bacterial infection. Therefore, an effective regenerative dressing is desiderated with the function of promoting revascularization and anti-bacteria. Herein, a multifunctional injectable composite hydrogel was prepared by incorporation of the cerium-containing bioactive glass (Ce-BG) into Gelatin methacryloyl (GelMA) hydrogel. The Ce-BG was synthesized by combining sol-gel method with template method, which maintained spherical shape, chemical structure and phase constitution of bioactive glass (BG). The Ce-BG/GelMA hydrogels had good cytocompatibility, promoted endothelial cells migration and tube formation by releasing Si ion. In vitro antibacterial tests showed that 5 mol % CeO₂-containing bioactive glass/GelMA (5/G) composite hydrogel exhibited excellent antibacterial properties. In vivo study demonstrated that the 5/G hydrogel could significantly improve wound healing in diabetic rats by accelerating the formation of granulation tissue, collagen deposition and angiogenesis. All in all, these results indicate that the 5/G hydrogel could enhance diabetic wound healing. Therefore, the development of multifunctional materials with antibacterial and angiogenic functions is of great significance to promote the repair of diabetic wound healing.

【 授权许可】

Unknown