Serum free thiols predict cardiovascular events and all-cause mortality in the general population: a prospective cohort study

BMC Medicine

S. la Bastide-van Gemert¹  Gerard Dijkstra²  Klaas Nico Faber²  Arno R. Bourgonje²  Anne M. Koning³  Marian L. C. Bulthuis³  Harry van Goor³  Robin P. F. Dullaart⁴  Lyanne M. Kieneker⁵  Stephan J. L. Bakker⁵  Ron T. Gansevoort⁵  Reinold O. B. Gans⁶  Amaal E. Abdulle⁶  Douwe J. Mulder⁶  Andreas Pasch⁷ 

[1] Department of Epidemiology, University of Groningen – University Medical Center Groningen;Department of Gastroenterology and Hepatology, University of Groningen – University Medical Center Groningen;Department of Pathology and Medical Biology, Section Pathology, University of Groningen – University Medical Center Groningen;Division of Endocrinology, Department of Internal Medicine, University of Groningen – University Medical Center Groningen;Division of Nephrology, Department of Internal Medicine, University of Groningen – University Medical Center Groningen;Division of Vascular Medicine, Department of Internal Medicine, University of Groningen – University Medical Center Groningen;Institute for Physiology and Pathophysiology, Johannes Kepler University Linz;

关键词: Oxidative stress;    Free thiols;    Cardiovascular disease;    Mortality;    Population study;   

DOI  :  10.1186/s12916-020-01587-w

来源: DOAJ

【 摘 要 】

Abstract Background Serum free thiols (R-SH, sulfhydryl groups) reliably reflect systemic oxidative stress. Since serum free thiols are rapidly oxidized by reactive species, systemic oxidative stress is generally associated with reduced serum free thiol levels. Free thiols associate with favorable disease outcomes in many patient cohorts, and the current hypothesis is that oxidative stress might also play an important role in cardiovascular disease. In this study, we aimed to establish the role of serum free thiols in the general population by investigating their relationship with the risk of cardiovascular (CV) events and all-cause mortality. Methods Participants (n = 5955) of the Prevention of REnal and Vascular ENd-stage Disease (PREVEND) cohort study from the general population were included. At baseline, serum levels of free thiols were quantified and adjusted to total protein levels. Protein-adjusted serum free thiol levels were studied for their associations with clinical and biochemical parameters, as well as with the risk of CV events and all-cause mortality. Results The mean protein-adjusted serum free thiol level was 5.05 ± 1.02 μmol/g of protein. Protein-adjusted serum free thiols significantly predicted the risk of CV events, even after adjustment for potential confounding factors (hazard ratio [HR] per doubling 0.68 [95% confidence interval [CI] 0.47–1.00], P = 0.048). Similarly, protein-adjusted serum free thiols were significantly predictive of the risk of all-cause mortality (HR per doubling 0.66 [95% CI 0.44–1.00], P = 0.050). Stratified analyses revealed lower HRs for subjects with a lower body mass index (BMI), without hypertension, and without diabetes. Conversely, HRs were lower in subjects with albuminuria. Conclusions In this large population-based cohort study, serum free thiols significantly predicted the risk of CV events and all-cause mortality. Our results highlight the potential significance and clinical applicability of serum free thiols since they are amendable to therapeutic intervention.

【 授权许可】

Unknown