Interleukin-15 in Outcomes of Pregnancy

International Journal of Molecular Sciences

Scott M. Gordon¹ 

[1] Division of Neonatology, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA;

关键词: Interleukin-15;    CD122;    pregnancy;    inflammation;    placenta;    natural killer cells;   

DOI  :  10.3390/ijms222011094

来源: DOAJ

【 摘 要 】

Interleukin-15 (IL-15) is a pleiotropic cytokine that classically acts to support the development, maintenance, and function of killer lymphocytes. IL-15 is abundant in the uterus prior to and during pregnancy, but it is subject to tight spatial and temporal regulation. Both mouse models and human studies suggest that homeostasis of IL-15 is essential for healthy pregnancy. Dysregulation of IL-15 is associated with adverse outcomes of pregnancy. Herein, we review producers of IL-15 and responders to IL-15, including non-traditional responders in the maternal uterus and fetal placenta. We also review regulation of IL-15 at the maternal–fetal interface and propose mechanisms of action of IL-15 to facilitate additional study of this critical cytokine in the context of pregnancy.

【 授权许可】

Unknown