Roles of Plasmacytoid Dendritic Cells in Gastric Cancer

Frontiers in Oncology

Yiwen Cheng¹  Jinpu Yang²  Feng Ji²  Xia Liu³  Jingchen Zhang³  Zongxin Ling⁴ 

[1] Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China;Department of Gastroenterology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China;Department of Intensive Care Unit, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China;Jinan Microecological Biomedicine Shandong Laboratory, Jinan, China;

关键词: gastric cancer;    Helicobacter pylori;    immune modulation;    plasmacytoid dendritic cells;    tumor microenvironment;   

DOI  :  10.3389/fonc.2022.818314

来源: DOAJ

【 摘 要 】

Gastric cancer (GC) is the fifth most common neoplasm and the third most deadly cancer in humans worldwide. Helicobacter pylori infection is the most important causative factor of gastric carcinogenesis, and activates host innate and adaptive immune responses. As key constituents of the tumor immune microenvironment, plasmacytoid dendritic cells (pDCs) are increasingly attracting attention owing to their potential roles in immunosuppression. We recently reported that pDCs have vital roles in the development of immunosuppression in GC. Clarifying the contribution of pDCs to the development and progression of GC may lead to improvements in cancer therapy. In this review, we summarize current knowledge regarding immune modulation in GC, especially the roles of pDCs in GC carcinogenesis and treatment strategies.

【 授权许可】

Unknown