Solid component tumor doubling time is a prognostic factor in non-small cell lung cancer patients

Journal of Cardiothoracic Surgery

Kentaro Miura¹  Ken-ichi Ito¹  Kazutoshi Hamanaka¹  Tomonobu Koizumi²  Satoshi Kawakami³  Nobutaka Kobayashi⁴ 

[1] Department of Breast, Endocrine and Thoracic Surgery, Shinshu University;Department of Comprehensive Cancer Therapy, Shinshu University;Department of Radiology, Shinshu University;Department of Thoracic Suegery, Japanese Red Cross Society Nagano Hospital;

关键词: Lung cancer;    Tumor doubling time;    Solid component;    Prognosis;   

DOI  :  10.1186/s13019-019-0879-x

来源: DOAJ

【 摘 要 】

Abstract Background Recently, several reports investigating tumor doubling times (TDTs) in lung cancer have demonstrated that lung cancer patients with shorter TDTs have poor prognoses. Although data have shown that the solid component of a tumor is clinically more important, relationships between solid component TDTs and lung cancer prognoses remain unclear. Methods To evaluate relationships between TDT and survival, we retrospectively evaluated 231 patients who underwent surgical resection for non-small cell lung cancer. The TDTs of whole and solid components were calculated using preoperative thin-slice chest computed tomography scans with a cut-off of 400 d between scans. Results Patients with short TDTs (< 400 d) both in the solid and whole components had poor prognoses. Among pathological stage I patients (n = 176), short solid component TDT (< 400 d) significantly influenced prognosis only in pathological stage IB patients. Moreover, we found that patients with shorter solid component TDTs had significantly worse prognosis compared with patients who showed shorter whole component TDTs. Conclusions Short solid component TDTs (< 400 d) could be a poor prognostic indicator for non-small cell lung cancer patients undergoing surgical resection; furthermore, clinicians should pay particularly close attention to cases with rapid growth of the solid tumor component.

【 授权许可】

Unknown