Prognostic role of the ABO blood types in Chinese patients with curatively resected non-small cell lung cancer: a retrospective analysis of 1601 cases at a single cancer center

Cancer Communications

Si-Yu Wang¹  Bao-Xiao Wang²  Chao-Feng Li²  Peng-Fei Xu³  Miao Xu⁴  Qun-Ai Huang⁴  Song-Liang Zhang⁵  Ning Li⁵  Cheng Yuan⁵  Wei Ou⁵ 

[1] Breast Tumor Center, Sun Yat-sen Memorial Hospital, Guangzhou, P.R. China;Department of Experimental Research, Sun Yat-sen University Cancer Center, Guangzhou, P.R. China;Department of Information Technology, Sun Yat-sen University Cancer Center, Guangzhou, P.R. China;Department of Thoracic Surgery, Sun Yat-sen University Cancer Center, Guangzhou, P.R. China;Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, P.R. China

关键词: The ABO blood types;    Lung cancer;    Prognosis;    Survival;   

DOI  :  10.1186/s40880-015-0054-2

学科分类：肿瘤学

来源: Springer

【 摘 要 】

A positive association between the ABO blood types and survival has been suggested in several malignancies. The aim of this study was to assess the role of the ABO blood types in predicting the prognosis of Chinese patients with curatively resected non-small cell lung cancer (NSCLC). We retrospectively analyzed 1601 consecutive Chinese patients who underwent curative surgery for NSCLC between January 1, 2005 and December 31, 2009. The relationship between the ABO blood types and survival was investigated. In addition, univariate and multivariate analyses were performed. Group 1 (patients with the blood type O or B) had significantly prolonged overall survival (OS) compared with group 2 (patients with the blood type A or AB), with a median OS of 74.9 months versus 61.5 months [hazard ratio (HR) 0.83; 95% confidence interval (CI) 0.72–0.96; P = 0.015]. Additionally, group 1 had significantly longer disease-free survival (DFS; HR 0.86; 95% CI 0.76–0.98; P = 0.022) and locoregional relapse-free survival (LRFS; HR 0.79; 95% CI 0.64–0.98; P = 0.024) than group 2. The association was not significantly modified by other risk factors for NSCLC, including smoking status, pathologic tumor-node-metastasis stage, pT category, pN category, and chemotherapy. There is an association between the ABO blood types and the survival of Chinese patients with resected NSCLC. Patients with the blood type O or B had significantly prolonged OS, DFS, and LRFS compared with those with the blood type A or AB.

【 授权许可】

CC BY