Design of Prototype Formulations for In Vitro Dermal Delivery of the Natural Antioxidant Ferulic Acid Based on Ethosomal Colloidal Systems

Cosmetics

CristhianJ. Yarce¹  ConstainH. Salamanca¹  CesarA. Londoño²  John Rojas² 

[1] Departamento de Ciencias Farmacéuticas, Facultad de Ciencias Naturales, Universidad Icesi, Calle 18 No. 122–135, Cali 76003, Colombia;Departamento de Farmacia, Facultad de Ciencias Farmacéuticas y Alimentarias, Universidad de Antioquia, Medellín 050010, Colombia;

关键词: ethosomes;    ferulic acid;    antioxidant;    dermal diffusion;    chemical stabilization;   

DOI  :  10.3390/cosmetics6010005

来源: DOAJ

【 摘 要 】

Ferulic acid (FA), a naturally occurring antioxidant, is currently used to prevent skin damage. However, FA is very unstable upon exposure to UV radiation and other factors, which decrease its shelf-life and effectiveness. Therefore, in this work, different prototypes of ethosomal FA vesicular systems were designed and developed to provide protection against different environmental factors. A two-level fractional factorial design was employed using particle size, zeta potential (ZP), incorporation efficiency (EE), polydispersity index (PDI), and the existing relationship between length and width of vesicles or aspect ratio (AR) as response variables. The optimal formulation was characterized using differential scanning calorimetry (DSC), infrared analysis, UV-Vis absorption, in-vitro permeability, and thermal degradation studies. Depending on the processing conditions, the EE and particle size varied between 3 and 87% and 470 and 1208 nm, respectively. Membrane studies indicated that the free product released ~4.8% of the compound, whereas the encapsulated material released ~7.1%. Because of their enhanced permeability, ethosomes could be a promising alternative for the topical administration of antioxidants to reduce the oxidative damage caused by solar radiation.

【 授权许可】

Unknown