Synthesis, Characterization, and Antioxidant Activity of Some 2-Methoxyphenols derivatives

Heterocyclic communications

article

Shaikha S. AlNeyadi¹  Naheed Amer²  Tony G. Thomas¹  Ruba Al Ajeil¹  Priya Breitener³  N Munawar¹ 

[1] Department of Chemistry, College of Science, UAE UniversityAl-Ain;Department of Pharmacology, College of Health and Science, UAE UniversityAl-Ain;General Requirement Department, Fathima College of Health Science

关键词: phenol;    antioxidant;    antiradical;    ferulic acid;    curcumin;   

DOI  :  10.1515/hc-2020-0112

学科分类：内科医学

来源: De Gruyter

【 摘 要 】

Oxidative stress is a causative factor in the pathophysiology of numerous diseases, such as diabetes, atherosclerosis, cancer, and neurodegenerative and cardiovascular diseases. Therapeutic antioxidants are promising candidates for preventing and treating conditions in which oxidative stress is a contributing factor. In this study, we report the design, synthesis and antioxidant activity of six compounds containing the 2-methoxyphenol moiety core structure. The synthesized derivatives were characterized using 1 H NMR, 13 C NMR, Fourier-transform infrared (FT-IR), and elemental analysis spectroscopy. The antioxidant properties of the compounds were evaluated using the 2,2-diphenyl-1-picryl-hydrazyl-hydrate (DPPH), 2,2’-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid (ABTS), and oxygen radical absorbance capacity (ORAC) assay. New phenolic acid-derived compounds with antioxidant activity were identified.

【 授权许可】

CC BY|CC BY-NC-ND