Bromopyrrole Alkaloids from the Sponge Agelas kosrae

Marine Drugs

Heegyu Kim¹  Ki-Bong Oh¹  Chung J. Sim²  Yeon-Ju Lee³  Hyi-Seung Lee³  Jongheon Shin⁴  Oh-Seok Kwon⁴  Dong-Chan Oh⁴  Sang Kook Lee⁴  Donghwa Kim⁴ 

[1] Department of Agricultural Biotechnology, College of Agriculture and Life Science, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-921, Korea;Department of Biological Science, College of Life Science and Nano Technology, Hannam University, 461-6 Jeonmin, Yuseong, Daejeon 305-811, Korea;Marine Natural Products Laboratory, Korea Institute of Ocean Science and Technology, P.O. Box 29, Seoul 425-600, Korea;Natural Products Research Institute, College of Pharmacy, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-742, Korea;

关键词: sceptrin;    pyrrole-imidazole alkaloids;    marine sponge;    anti-angiogenesis;    isocitrate lyase;    bioactive marine natural products;   

DOI  :  10.3390/md16120513

来源: DOAJ

【 摘 要 】

Two new sceptrin derivatives (1,2) and eight structurally-related known bromopyrrole-bearing alkaloids were isolated from the tropical sponge Agelas kosrae. By a combination of spectroscopic methods, the new compounds, designated dioxysceptrin (1) and ageleste C (2), were determined to be structural analogs of each other that differ at the imidazole moiety. Dioxysceptrin was also found to exist as a mixture of α-amido epimers. The sceptrin alkaloids exhibited weak cytotoxicity against cancer cells. Compounds 1 and 2 also moderately exhibited anti-angiogenic and isocitrate lyase-inhibitory activities, respectively.

【 授权许可】

Unknown