Further Investigation of the Mediterranean Sponge Axinella polypoides: Isolation of a New Cyclonucleoside and a New Betaine

Marine Drugs

Marialuisa Menna¹  Anna Aiello¹  Filomena D𠆚niello¹  Ernesto Fattorusso¹  Concetta Imperatore¹  Paolo Luciano² 

[1] The NeaNat Group, Department of Chemistry of Natural Products, University of Naples “Federico II”, Via D. Montesano 49, Napoli 80131, Italy;C.S.I.A.S. (Interdepartmental Center of Instrumental Analysis), University of Naples “Federico II”, Via D. Montesano 49, Napoli 80131, Italy;

关键词: natural products;    sponges;    Axinellidae;    pyrrole-imidazole alkaloids;    taxon-specificity;   

DOI  :  10.3390/md10112509

来源: mdpi

【 摘 要 】

An exhaustive exploration into the metabolic content of the Mediterranean sponge Axinella-polypoides resulted in the isolation of the new betaine 5 and the new cyclonucleoside 8. The structures of the new metabolites were elucidated by spectroscopic methods assisted by computational methods. The analysis also provided evidence that the sponge does not elaborate pyrrole-imidazole alkaloids (PIAs) but, interestingly, it was shown to contain two already known cyclodipeptides, compounds 9 (verpacamide A) and 10.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.