L-Lysine α-Oxidase: Enzyme with Anticancer Properties

Pharmaceuticals

Vadim S. Pokrovsky¹  Gulalek Babayeva¹  Elena V. Lukasheva¹  Dmitry D. Zhdanov²  Saida Sh. Karshieva³ 

[1] Department of Biochemistry, Peoples’ Friendship University of Russia (RUDN University), Miklukho—Maklaya Street 6, 117198 Moscow, Russia;Institute of Biomedical Chemistry, Pogodinskaya Street 10/8, 119121 Moscow, Russia;Laboratory of Combined Treatment, N.N. Blokhin Cancer Research Center, Kashirskoe Shosse 24, 115478 Moscow, Russia;

关键词: anticancer enzymes;    tumor therapy;    L-amino acid oxidase;    L-lysine α-oxidase;    L-lysine;    colon cancer treatment;   

DOI  :  10.3390/ph14111070

来源: DOAJ

【 摘 要 】

L-lysine α-oxidase (LO), one of L-amino acid oxidases, deaminates L-lysine with the yield of H₂O₂, ammonia, and α-keto-ε-aminocaproate. Multiple in vitro and in vivo studies have reported cytotoxic, antitumor, antimetastatic, and antitumor activity of LO. Unlike asparaginase, LO has a dual mechanism of action: depletion of L-lysine and formation of H₂O₂, both targeting tumor growth. Prominent results were obtained on murine and human tumor models, including human colon cancer xenografts HCT 116, LS174T, and T47D with maximum T/C 12, 37, and 36%, respectively. The data obtained from human cancer xenografts in immunodeficient mice confirm the potential of LO as an agent for colon cancer treatment. In this review, we discuss recently discovered molecular mechanisms of biological action and the potential of LO as anticancer enzyme.

【 授权许可】

Unknown