Pathological Metabolism of Methionine in Malignant Cells Is a Potential Target for the Antitumor Therapy

Kliničeskaâ onkogematologiâ

VS Pokrovskii¹  DZh Davydov¹  EM Treshchalina¹  NV Anufrieva²  TV Demidkina²  EA Morozova²  DD Zhdanov³ 

[1] NN Blokhin Russian Cancer Research Center, 24 Kashirskoye sh., Moscow, Russian Federation, 115478;VA Engelhardt Institute of Molecular Biology, 32 Vavilova str., Moscow, Russian Federation, 119991;VN Orekhovich Institute of Biomedical Chemistry, 10 bld. 8 Pogodinskaya str., Moscow, Russian Federation, 119121;

关键词: methionine-γ-liase;    methionine;    methionine dependency;    cancer cells;    cancer;    anticancer enzymes;    antitumor therapy;   

DOI  :  10.21320/2500-2139-2017-10-3-324-332

来源: DOAJ

【 摘 要 】

This review presents the characteristics of the cellular metabolism of methionine, as well as known data on the mechanisms of the development of methionine dependence in malignant cells. The possibilities of using a non-methionine diet for the control of the tumor growth in patients with various forms of cancer are considered. The newest information about methionine-γ-lyase, an enzyme providing elimination of methionine from plasma, is grouped and summarised. Its role as a potential antitumor enzyme is disclosed. Data on methionine-γ-lyase producers, activity of this enzyme, obtained from various sources, and information on tumor models and cell cultures, showing methionine dependence are summarised.

【 授权许可】

Unknown