Microglia in Alzheimer’s Disease: A Target for Therapeutic Intervention

Frontiers in Cellular Neuroscience

Huiling Hu¹  Zicheng Wang²  Meng Zhao²  Guimei Zhang²  Li Sun² 

[1] Department of Intensive Care Unit, The Affiliated Hospital of Qingdao University, Shandong, China;Department of Neurology and Neuroscience Center, The First Hospital of Jilin University, Jilin University, Changchun, China;

关键词: Alzheimer’s disease;    β-amyloid;    microglia;    neuroinflammation;    tau;   

DOI  :  10.3389/fncel.2021.749587

来源: DOAJ

【 摘 要 】

Alzheimer’s disease (AD) is one of the most common types of age-related dementia worldwide. In addition to extracellular amyloid plaques and intracellular neurofibrillary tangles, dysregulated microglia also play deleterious roles in the AD pathogenesis. Numerous studies have demonstrated that unbridled microglial activity induces a chronic neuroinflammatory environment, promotes β-amyloid accumulation and tau pathology, and impairs microglia-associated mitophagy. Thus, targeting microglia may pave the way for new therapeutic interventions. This review provides a thorough overview of the pathophysiological role of the microglia in AD and illustrates the potential avenues for microglia-targeted therapies, including microglial modification, immunoreceptors, and anti-inflammatory drugs.

【 授权许可】

Unknown