An Outbreak of Botulism: Evaluation of the 24 Patients

Flora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi

Gamze ÇAN¹  Cavit BOZ²  Zekeriya ALİOĞLU²  Rahmet ÇAYLAN³  Kemalettin AYDIN³  İftihar KÖKSAL³  Müge ÜSTÜNAKIN³  Uğur KOSTAKOĞLU³ 

[1] Karadeniz Teknik Üniversitesi Tıp Fakültesi, Halk Sağlığı Anabilim Dalı,;Karadeniz Teknik Üniversitesi Tıp Fakültesi, Nöroloji Anabilim Dalı, TRABZON;Karadeniz Teknik Üniversitesi Tıp Fakültesi, İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Anabilim Dalı,;

关键词: Botulism;    Food poisoning;    Outbreak;   

DOI  :  

来源: DOAJ

【 摘 要 】

Botulism is a neuroparalytic disease caused by the microorganism Clostridium botulinum, which secretes toxins that affect the peripheral synapses. In this study, epidemiological and clinical features of the outbreak of botulism in the Ayvadere village, Trabzon in April 2000 are evaluated and discussed. The material responsible for contamination was identified as home-made cheese, a traditional food in the region. The outbreak affected a total of 24 people of which 16 were men and 8 were women. The mean value of patients age was 39.6 ± 14.9 (16-72) and the mean duration of incubation was 86.5 ± 64 (8-192) hours. The frequency symptoms and signs were as follows; dryness of mouth and fatigue 96%, visual disturbances 83%, dysphagia 79%, decrease in gag reflex 75%, diplopia 63%. The patients were classifed into two groups: Group 1 (n= 11) consisting of patients with generalized symptoms and respiratory distress and Group 2 (n= 13) consisting of patients without respiratory distress symptoms. All patients were followed after hospitalization. In Group 1, 5 patients underwent tracheotomy and of these 4 necessiated mechanical ventilation. Antitoxin was available for only 8 patients in Group 1 and hypersensitivity to antitoxin developed in one patient. Mean duration of stay in hospital in Group 1 was 20.8 ± 15.9 days for those receiving antitoxin (n= 8) and 35 ± 12.1 days for those that did not receive antitoxin. Three patients who died belonged to the Group 1 and were associated with severe respiratory distress. The mean duration of incubation periods for the fatal cases and survived cases was 26.6 ± 20.1 and 95.1 ± 63.7 hours and the patients mean age was 45.6 ± 19.4 and 38.7 ± 14.6 respectively. However no significant difference was present between the groups with respect to incubation (p> 0.05). In the follow-up after three months persistance of complaints such as fatigue and muscular weakness were noted. This is the largest series of botulismus outbreak reported from Turkey, diagnosed in view of clinical and epidemiological features further supported by EMG findings.

【 授权许可】

Unknown