Short-Lived Immunity After 17DD Yellow Fever Single Dose Indicates That Booster Vaccination May Be Required to Guarantee Protective Immunity in Children

Frontiers in Immunology

Carla Magda Domingues¹  Elaine Maria Souza-Fagundes²  Alessandro Pecego Martins Romano³  Luiz Antônio Bastos Camacho⁴  Pedro Luiz Tauil⁵  Pedro Fernando Costa Vasconcelos⁶  Laise Rodrigues Reis⁷  Cristina Toscano Fonseca⁷  Christiane Costa-Pereira⁷  Ismael Artur da Costa-Rocha⁷  Ana Carolina Campi-Azevedo⁷  Vanessa Peruhype-Magalhães⁷  Jordana Grazziela Coelho-dos-Reis⁷  Olindo Assis Martins-Filho⁷  Andréa Teixeira-Carvalho⁷  Juliana Vaz de Melo Mambrini⁷  Lis Ribeiro Antonelli⁷  Iramaya Rodrigues Caldas⁷  Maria de Lourdes de Sousa Maia⁸  Sheila Maria Barbosa de Lima⁸  Marcos da Silva Freire⁸  Akira Homma⁸  Tatiana Guimarães de Noronha⁸  Marisol Simões⁸  Reinaldo de Menezes Martins⁸  Jandira Aparecida Campos Lemos⁹  José Geraldo Leite Ribeiro^1,10 

[1] 0Programa Nacional de Imunizações – Secretaria de Vigilância em Saúde, Ministério da Saúde, Brasilia, Brazil;Departamento de Fisiologia e Biofísica, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil;Departamento de Imunização e Doenças Transmissíveis (DEIDT) – Secretaria de Vigilância em Saúde, Ministério da Saúde, Brasilia, Brazil;Escola Nacional de Saúde Pública – FIOCRUZ, Rio de Janeiro, Brazil;Faculdade de Medicina, Universidade de Brasília, Brasilia, Brazil;Instituto Evandro Chagas, Ananindeua, Brazil;Instituto René Rachou, Fundação Oswaldo Cruz – FIOCRUZ-Minas, Belo Horizonte, Brazil;Instituto de Tecnologia em Imunobiológicos Bio-Manguinhos – FIOCRUZ, Rio de Janeiro, Brazil;Secretaria Municipal de Saúde de Belo Horizonte, Belo Horizonte, Brazil;Secretaria do Estado de Saúde de Minas Gerais, Belo Horizonte, Brazil;

关键词: yellow fever;    17DD vaccine;    children;    neutralizing antibodies;    cellular memory;   

DOI  :  10.3389/fimmu.2019.02192

来源: DOAJ

【 摘 要 】

The Yellow Fever (YF) vaccination is recommended for people living in endemic areas and represents the most effective strategy to reduce the risk of infection. Previous studies have warned that booster regimens should be considered to guarantee the long-term persistence of 17DD-YF-specific memory components in adults living in areas with YF-virus circulation. Considering the lower seroconversion rates observed in children (9–12 months of age) as compared to adults, this study was designed in order to access the duration of immunity in single-dose vaccinated children in a 10-years cross-sectional time-span. The levels of neutralizing antibodies (PRNT) and the phenotypic/functional memory status of T and B-cells were measured at a baseline, 30–45 days, 1, 2, 4, 7, and 10 years following primary vaccination. The results revealed that a single dose induced 85% of seropositivity at 30–45 days and a progressive time-dependent decrease was observed as early as 2 years and declines toward critical values (below 60%) at time-spans of ≥4-years. Moreover, short-lived YF-specific cellular immunity, mediated by memory T and B-cells was also observed after 4-years. Predicted probability and resultant memory analysis emphasize that correlates of protection (PRNT; effector memory CD8+ T-cells; non-classical memory B-cells) wane to critical values within ≥4-years after primary vaccination. Together, these results clearly demonstrate the decline of 17DD-YF-specific memory response along time in children primarily vaccinated at 9–12 months of age and support the need of booster regimen to guarantee the long-term persistence of memory components for children living in areas with high risk of YF transmission.

【 授权许可】

Unknown