A Pilot Study of Home-Based Exercise and Personalized Nutrition Counseling Intervention in Endometrial Cancer Survivors

Frontiers in Oncology

Gloria Broadwater¹  Meghan Channell²  David B. Bartlett³  Kim M. Huffman⁴  Patricia A. Wilkes⁵  Amanda R. Schwartz⁶  Kimberly C. Nolte⁷  Angeles Alvarez Secord⁷  Johanna L. Johnson⁸ 

[1] Department of Biostatistics and Bioinformatics, Duke Cancer Institute, Duke University Medical Center, Durham, NC, United States;Department of Clinical Research, Duke Cancer Institute, Duke University Medical Center, Durham, NC, United States;Department of Medicine, Division of Medical Oncology, Duke University Hospital, Durham, NC, United States;Department of Medicine, Division of Rheumatology, Duke University Hospital, Durham, NC, United States;Department of Nutrition Services, Duke University Hospital, Durham, NC, United States;Department of Obstetrics and Gynecology, Duke University Hospital, Durham, NC, United States;Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Duke Cancer Institute, Duke University Health System, Durham, NC, United States;Duke Molecular Physiology Institute, Duke Center for Living, Duke University, Durham, NC, United States;

关键词: endometrial cancer;    obesity;    cardiovascular disease;    exercise intervention study;    nutrition intervention program;   

DOI  :  10.3389/fonc.2021.669961

来源: DOAJ

【 摘 要 】

IntroductionTo assess the feasibility of a home-based aerobic exercise and nutrition counseling intervention and effect on cardiorespiratory fitness, cardiovascular disease risk profile, and immune response in obese endometrial cancer survivors.MethodsA longitudinal pilot study assessed a 12-week home-based aerobic exercise and nutrition counseling intervention in obese endometrial cancer survivors. The primary outcome was feasibility defined as 80% adherence to weekly walking sessions calculated among individuals that completed the intervention. Secondary outcomes comprised pre- and post-intervention differences in cardiorespiratory fitness, cardiovascular risk factors, and T-cell function. Descriptive statistics summarized data. Wilcoxon sign tests identified differences between and pre and post-intervention variables.ResultsNineteen women with stage 1 endometrial cancer consented; 9 withdrew and one was a screen failure. Median adherence to weekly walking sessions was 83.3%. Body composition was significantly altered with a reduction in median fat mass from 52.5 kg to 46.9 kg (p=0.04), and BMI from 37.5 kg/m2 to 36.2 kg/m2 (p = 0.004). There was no significant difference in cardiorespiratory fitness or cardiovascular parameters. The percentage of CD4+ and CD8+ T-cells producing IFNγ towards MAGE-A4 significantly increased from and 5.9% to 7.2% (p=0.043) and 13.9% to 14.8% (p=0.046), respectively. There were 3 related adverse events: hip pain, back sprain, and abdominal pain.DiscussionOur home-based exercise and nutrition counseling program was feasible based on 80% adherence to walking sessions and favored altered body composition. However, the discontinuation rate was high and further research is needed to overcome barriers to implementation. Improvement in cardiovascular parameters will most likely require longer and more intensive programs.

【 授权许可】

Unknown