Synthesis of New Acadesine (AICA-riboside) Analogues Having Acyclic d-Ribityl or 4-Hydroxybutyl Chains in Place of the Ribose

Molecules

关键词: AICAR;    ZMP;    acadesine;    AMPK;    AMPK activation;    imidazole nucleosides;    nucleoside analogues;    modified nucleosides;    acyclic nucleosides;    acyclic nucleotides;   

DOI  :  10.3390/molecules18089420

来源: DOAJ

【 摘 要 】

The antiviral activity of certain acyclic nucleosides drew our attention to the fact that the replacement of the furanose ring by an alkyl group bearing hydroxyl(s) could be a useful structural modification to modulate the biological properties of those nucleosides. Herein, we report on the synthesis of some novel acadesine analogues, where the ribose moiety is mimicked by a d-ribityl or by a hydroxybutyl chain.

【 授权许可】

Unknown