Metabolic Changes Induced by Purinergic Signaling: Role in Food Intake

Frontiers in Pharmacology

Mariachiara Zuccarini¹  Patrizia Di Iorio¹  Maurizio Ronci³  Vanni Caruso⁴  Ishaq Muhammad⁵ 

[1] Center for Advanced Studies and Technologies (CAST), University of Chieti-Pescara, Chieti, Italy;Department of Medical, Oral and Biotechnological Sciences, University of Chieti-Pescara, Chieti, Italy;Department of Pharmacy, University of Chieti-Pescara, Chieti, Italy;Institute for Research on Pain, ISAL‐Foundation, Rimini, Italy;School of Pharmacy and Pharmacology, University of Tasmania, Hobart, TAS, Australia;

关键词: purinergic receptors;    food intake;    metabolic homeostasis;    orexigen and anorexigen neurons;    obesity;   

DOI  :  10.3389/fphar.2021.655989

来源: DOAJ

【 摘 要 】

The purinergic signalling has a well-established role in the regulation of energy homeostasis, but there is growing evidence of its implication in the control of food intake. In this review, we provide an integrative view of the molecular mechanisms leading to changes in feeding behaviour within hypothalamic neurons following purinergic receptor activation. We also highlight the importance of purinergic signalling in metabolic homeostasis and the possibility of targeting its receptors for therapeutic purposes.

【 授权许可】

Unknown