The Presence of Serum TgAb Suggests Lower Risks for Glucose and Lipid Metabolic Disorders in Euthyroid General Population From a National Survey

Frontiers in Endocrinology

Youmin Wang¹  Lanjie He²  Bingyin Shi³  Mei Zhu⁴  Xiaoyang Lai⁵  Weiping Teng⁶  Hui Sun⁷  Yanbo Li⁸  Xulei Tang⁹  Haiyi Chi^1,10  Nanwei Tong^1,11  Guixia Wang^1,12  Eryuan Liao^1,13  Jin-an Zhang^1,14  Chao Liu^1,15  Libin Liu^1,16  Zhen Ye^1,17  Guijun Qin^1,18  Qiao Zhang^1,19  Yingfen Qin^2,20  Lihui Zhang^2,21  Huibiao Quan^2,22  Jun Zhu^2,23  Yongze Li^2,24  Yiyang Gao^2,24  Zhongyan Shan^2,24  Xiaochun Teng^2,24  Jinjia Zhang^2,24  Xiaoguang Shi^2,24  Jing Li^2,24  Di Teng^2,24  Lihui Yang^2,25  Li Yan^2,26  Jianming Ba^2,27  Yongli Yao^2,28  Bing Chen^2,29  Jianling Du^3,30  Jing Yang^3,31  Yuanming Xue^3,32 

[1] Health Science Affiliated Zhoupu Hospital, Shanghai, China;0Department of Endocrinology, Cardiovascular and Cerebrovascular Disease Hospital of Ningxia Medical University, Yinchuan, China;0Department of Endocrinology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China;0Department of Endocrinology, The First Affiliated Hospital of Xinjiang Medical University, Ürümqi, China;1Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Nanchang University, Nanchang, China;1Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin, China;1Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China;2Department of Endocrinology, The First Affiliated Hospital of Harbin Medical University, Harbin, China;2Department of Endocrinology, The First Hospital of Lanzhou University, Lanzhou, China;3Department of Endocrinology, Hohhot First Hospital, Hohhot, China;3State Key Laboratory of Biotherapy, Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, China;4Department of Endocrinology and Metabolism, The First Hospital of Jilin University, Changchun, China;4Department of Endocrinology and Metabolism, The Second Xiangya Hospital, Central South University, Changsha, China;;5Department of Endocrinology, Shanghai University of Medicine &5Research Center of Endocrine and Metabolic Diseases, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China;6Department of Endocrinology and Metabolism, Fujian Institute of Endocrinology, Fujian Medical University Union Hospital, Fuzhou, China;6Department of Endocrinology, The First Hospital of Anhui Medical University, Hefei, China;7Division of Endocrinology, Department of Internal Medicine, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, China;7Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, China;8Department of Endocrine, First Affiliated Hospital of Guangxi Medical University, Nanning, China;8Department of Endocrinology and Metabolism, Affiliated Hospital of Guiyang Medical University, Guiyang, China;9Department of Endocrinology, Hainan General Hospital, Haikou, China;9Department of Endocrinology, Second Hospital of Hebei Medical University, Shijiazhuang, China;Department of Endocrinology and Metabolism, Institute of Endocrinology, The First Affiliated Hospital of China Medical University, Shenyang, China;Department of Endocrinology and Metabolism, People's Hospital of Tibet Autonomous Region, Lhasa, China;Department of Endocrinology and Metabolism, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China;Department of Endocrinology, Chinese PLA General Hospital, Beijing, China;Department of Endocrinology, Qinghai Provincial People's Hospital, Xining, China;Department of Endocrinology, Southwest Hospital, Third Military Medical University, Chongqing, China;Department of Endocrinology, The First Affiliated Hospital of Dalian Medical University, Dalian, China;Department of Endocrinology, The First Hospital of Shanxi Medical University, Taiyuan, China;Department of Endocrinology, The First People's Hospital of Yunnan Province, Kunming, China;

关键词: glucose;    lipid;    TPOAb;    TgAb;    IFG;    hypertriglyceridemia;   

DOI  :  10.3389/fendo.2020.00139

来源: DOAJ

【 摘 要 】

Purpose: The expressions of antibodies against thyroid peroxidase (TPOAb) and thyroglobulin (TgAb) are very common in the sera of patients with autoimmune thyroid diseases (AITD). The relationship between thyroid autoantibodies and the occurrence of glucose and lipid metabolic disorders remains unclear. This study was performed to investigate the correlation between the presence of serum TPOAb/TgAb and those metabolic disorders in euthyroid general population.Methods: The data of this study were derived from the Thyroid Disease, Iodine status, and Diabetes National epidemiological (TIDE) survey from all 31 provinces of mainland China. A total of 17,964 euthyroid subjects including 5,802 males (4,000 with TPOAb−TgAb− and 1,802 with TPOAb+/TgAb+) and 12,162 females (8,000 with TPOAb−TgAb− and 4,162 with TPOAb+/TgAb+) were enrolled in this study. The blood glucose and lipid levels were compared between individuals with TPOAb−TgAb− and those with TPOAb+TgAb−, TPOAb−TgAb+, TPOAb+TgAb+.Results: Both fasting blood glucose (FBG) concentration and the proportion of individuals with impaired FBG (IFG) showed the decreased trends in TPOAb−TgAb+ males as compared with TPOAb−TgAb− men. There were significantly lower FBG and higher HDL-C levels as well as tendencies toward decreased incidences of IGT and hypertriglyceridemia in TPOAb−TgAb+ females when compared with TPOAb−TgAb− women. Binary logistic regression analysis further showed that serum TgAb single positivity in males was an independent protective factor for IFG with an OR of 0.691 (95% CI, 0.503–0.949). For females, serum TgAb single positivity was an independent protective factor for hypertriglyceridemia with an OR of 0.859 (95% CI, 0.748–0.987). Trend test showed that with the increase of serum TgAb level, there were significant decreases in the prevalence of IFG among the men with TSH ≤ 2.5 mIU/L and that of hypertriglyceridemia in the women, especially among non-obese females.Conclusion: Serum TgAb single positivity may imply a reduced risk of IFG in euthyroid men and that of hypertriglyceridemia in euthyroid women. The mechanisms for the independent protective roles of TgAb await further investigation.

【 授权许可】

Unknown