Risk Factors of Bone Loss in Spondyloarthritis

Acta Medica Iranica

Dhia Kaffel¹  Meriem Sellami¹  Hanene Ferjani¹  Abir Kasraoui¹  Wafa Hamdi¹  Kaouther Maatallah¹  Mohamed Montacer Kchir¹ 

[1] Department of Rheumatology, Faculty of Medicine of Tunis, Kassab Institute, University of Tunis El Manar, Tunis, Tunisia;

关键词: Bone density;    Bone loss;    Dual-energy X-ray absorptiometry (DXA);    Osteoporosis;    Spondyloarthritis;   

DOI  :  10.18502/acta.v58i10.4910

来源: DOAJ

【 摘 要 】

We aimed to determine the bone mineral status in patients with spondyloarthritis (SA), and to assess the impact of parameters associated with bone loss on bone mineral density (BMD). Seventy-five patients (62 men) with SA fulfilling the modified New York criteria were included in a cross-sectional study during one year. BMD was assessed in all patients using dual-energy X-ray absorptiometry. The patient’s average age was 36.8 years. Sixty-five patients (86.6%) had bone loss. The lumbar spine was the site most affected by osteoporosis (37%). Bone loss was significantly associated with low BMI, peripheral joint involvement, active disease (high ASDASESR and BASDAI), vitamin D insufficiency, elevated erythrocyte sedimentation rate (ESR) and c-reactive protein, as well as high BASRI, high BASMI, and with the use of csDMARDs or anti-TNF alpha therapy. The disease activity, biologic inflammation, low vitamin D level, peripheral joint involvement, and structural damage were the major factors that induce bone loss in SA patients. Multivariate analysis showed that only high ESR level (AOR 19.9, 95% CI) and peripheral arthritis (AOR 14.5, 95% IC) were independent risk factors of bone loss. Our study shows that bone loss was a multifactorial complication of SA.

【 授权许可】

Unknown