Consumption of the edible sea urchin Mesocentrotus nudus attenuates body weight gain and hepatic lipid accumulation in mice

Journal of Functional Foods

Hiromi Matsusaki¹  Hisanori Minami²  Naonobu Tsutsumi³  Osamu Nishimiya³  Ryoko Yamamoto⁴  Mami Sakashita⁴  Naoki Morita⁴  Masashi Hosokawa⁵  Toshiro Matsui⁵  Yutaka Itabashi⁵  Kazuhiro Ura⁵ 

[1] Corresponding author at: Faculty of Agriculture and Life Science, Hirosaki University, 3 Bunkyo-cho, Hirosaki, Aomori 036-8561, Japan.;Division of Bioresource and Bioenvironmental Sciences, Faculty of Agriculture, Graduate School of Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan;Bioproduction Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), 2-17-2-1 Tsukisamu-higashi, Toyohira-ku, Sapporo 062-8517, Japan;Department of Food and Health Sciences, Faculty of Environmental and Symbiotic Sciences, Prefectural University of Kumamoto, 3-1-100 Tsukide, Higashi-ku, Kumamoto 862-8502, Japan;Graduate School of Fisheries Science, Hokkaido University, 3-1-1 Minato-cho, Hakodate 041-8611, Japan;

关键词: Sea urchin;    Polyunsaturated fatty acid;    Obesity;    Non-alcoholic fatty liver disease;    Uncoupling protein-1;   

DOI  :  

来源: DOAJ

【 摘 要 】

The beneficial health effects of edible sea urchin consumption in mice fed a normal (ND) or high-fat diet (HFD) were investigated in this study. Notably, sea urchin-administered (250, 500, 1000 mg/kg) mice exhibited lower body, liver, and visceral fat weights, lower plasma levels of aspartate aminotransferase and alanine aminotransferase, and lower hepatic triacylglycerol levels than those fed carboxymethyl cellulose (CMC). Despite the high levels of cholesterol found in sea urchins, intake of these organisms had no effect on plasma cholesterol levels among the mice tested. Additionally, sea urchin consumption resulted in enhanced levels of arachidonic acid and docosahexaenoic acid within mouse livers. Lastly, mice fed HFD with sea urchin (500 mg/kg) exhibited increased mRNA expression of uncoupling protein-1 within brown adipose tissue, compared with those fed HFD with CMC. In conclusion, consumption of sea urchin might provide a protective effect against the development of obesity and/or nonalcoholic fatty liver disease.

【 授权许可】

Unknown