Emerging Promise of Cannabinoids for the Management of Pain and Associated Neuropathological Alterations in Alzheimer’s Disease

Frontiers in Pharmacology

May N. Bin-Jumah¹  Mohamed M. Abdel-Daim³  Hesham R. El-Seedi⁴  Ghulam Md Ashraf⁵  Simona G. Bungau⁶  Dewan Md. Sumsuzzman⁷  Asma Perveen⁹  Shaker A. Mousa^1,11  Abdullah Al Mamun^1,12  Md. Sahab Uddin^1,12 

[1] 0Department of Biology, College of Science, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia;1Department of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia;2Pharmacology Department, Faculty of Veterinary Medicine, Suez Canal University, Ismailia, Egypt;Department of Chemistry, Faculty of Science, Menoufia University, Shebin El-Koom, Egypt;Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia;Department of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, Oradea, Romania;Department of Pharmacy, Southeast University, Dhaka, Bangladesh;Division of Pharmacognosy, Department of Medicinal Chemistry, Uppsala University, Uppsala, Sweden;Glocal School of Life Sciences, Glocal University, Saharanpur, India;King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia;Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, New York, NY, United States;Pharmakon Neuroscience Research Network, Dhaka, Bangladesh;

关键词: cannabinoids;    marijuana;    endocannabinoid system;    pain;    Alzheimer’s disease;   

DOI  :  10.3389/fphar.2020.01097

来源: DOAJ

【 摘 要 】

Alzheimer’s disease (AD) is an irreversible chronic neurodegenerative disorder that occurs when neurons in the brain degenerate and die. Pain frequently arises in older patients with neurodegenerative diseases including AD. However, the presence of pain in older people is usually overlooked with cognitive dysfunctions. Most of the times dementia patients experience moderate to severe pain but the development of severe cognitive dysfunctions tremendously affects their capability to express the presence of pain. Currently, there are no effective treatments against AD that emphasize the necessity for increasing research to develop novel drugs for treating or preventing the disease process. Furthermore, the prospective therapeutic use of cannabinoids in AD has been studied for the past few years. In this regard, targeting the endocannabinoid system has considered as a probable therapeutic strategy to control several associated pathological pathways, such as mitochondrial dysfunction, excitotoxicity, oxidative stress, and neuroinflammation for the management of AD. In this review, we focus on recent studies about the role of cannabinoids for the treatment of pain and related neuropathological changes in AD.

【 授权许可】

Unknown