Dupilumab Versus Cyclosporine for the Treatment of Moderate-to-Severe Atopic Dermatitis in Adults: Indirect Comparison Using the Eczema Area and Severity Index

Acta Dermato-Venereologica

Lieneke F.M. Ariëns¹  Zhen Chen²  Elena Rizova²  Gaëlle Bégo-Le Bagousse²  Harmieke van Os-Medendorp²  Abhijit Gadkari²  Marjolein De Bruin-Weller²  Emi Terasawa²  Yufang Lu²  Andreas Kuznik²  Neil M.H. Graham²  Laurent Eckert²  Gianluca Pirozzi²  Rajeev Ayyagari² 

[1] Department of Dermatology and Allergology, UMC Utrecht, 3508 GA Utrecht, The Netherlands. ;;

关键词: adult;    atopic dermatitis;    cyclosporine;    dupilumab;    Eczema Area and Severity Index;    eczema;   

DOI  :  10.2340/00015555-3219

来源: DOAJ

【 摘 要 】

Dupilumab is approved for uncontrolled moderate-to-severe atopic dermatitis (AD); cyclosporine is approved for severe AD for <1 year. The efficacy/effectiveness of these treat­ments was compared indirectly. Regression models used pooled patient-level data to estimate response (Eczema Area and Severity Index (EASI) EASI-50/EASI-75 at weeks 12–16 and 24–30) to dupilumab 300 mg every 2 weeks (CHRONOS [NCT02260986]) or cyclosporine (University Medical Center). Models were adjusted for sex, baseline EASI, and thymus and activation-regulated chemokine level. A total of 106 patients received dupilumab (+ topical cortico­steroids; + TCS), and 57 received cyclosporine (+ TCS). Among University Medical Center patients, estimated EASI-50 responders were, dupilumab vs. cyclosporine, 91% vs. 77% (p = 0.038; weeks 12–16), and 96% vs. 67% (p <0.0001; weeks 24–30); EASI-75 responders were 78% vs. 56% (p = 0.016; weeks 12–16) and 80% vs. 47% (p <0.001; weeks 24–30). Among CHRONOS patients, estimated EASI-50 responders were 90% vs. 74% (p <0.038; weeks 12–16) and 92% vs. 53% (p < 0.0001; weeks 24–30); EASI-75 responders were 75% vs. 52% (p = 0.016; weeks 12–16) and 74% vs. 40% (p <0.001; weeks 24–30), respectively. These results suggest a higher relative efficacy of dupilumab vs. cyclosporine.

【 授权许可】

Unknown