A 200-year history of Parkinson's disease

Chinese Journal of Contemporary Neurology and Neurosurgery

Yong JI¹  Xiao-dan WANG¹ 

[1]Department of Neurology, Tianjin Huanhu Hospital, Tianjin 300350, China

关键词: Parkinson disease;    History of medicine;    Review;   

DOI  :  

来源: DOAJ

【 摘 要 】

In 1817, Dr. James Parkinson firstly described the concept, duration, andclinical characteristics of Parkinson's disease (PD). However, it was widelyknown until 1877 when it was named "Parkinson's disease" by Dr. Jean-MartinCharcot. In 1912, Frederic Henry Lewy, a neuropathologist, found a specialabnormal protein in nerve cells of PD patients. Medical profession began tolearn about the pathology of PD only when Konstantin Tretiakoff named thespecial abnormal protein "Lewy body (LB)" in 1919 and believed the main lesionof PD was in substantia nigra. In 1867, the German psychiatrist LeopoldOrdenstein found that PD patients hadsymptoms of excitement of parasympatheticnerve, such as salivation, and treated them with belladonna alkaloids, thuscreating a precedent for medical treatment of PD. After 1950's, the researchersgradually found that Lewy body was common in substantia nigra and locuscoeruleus of PD patients and then gradually determined the pathological featuresof PD. The Swedish scientist Arvid Carlsson and Japanese neurologist Isamu Sanofound dopamine abnormalities in the brain of PD patients, and thus researchedand developed levodopa. PD has a history of 200 years, and we expect newresearch of PD studies.

 

DOI: 10.3969/j.issn.1672-6731.2017.01.002

【 授权许可】

Unknown