1H NMR Relaxometric Analysis of Paramagnetic Gd2O3:Yb Nanoparticles Functionalized with Citrate Groups

Inorganics

Giorgio Gatti¹  Fabio Carniato¹ 

[1] Department of Sciences and Technological Innovation, University of Eastern Piedmont, V. le T. Michel 11, 15121 Alessandria, Italy;

关键词: paramagnetic properties;    Gadolinium oxide;    relaxation agents;    nanoparticles;   

DOI  :  10.3390/inorganics7030034

来源: DOAJ

【 摘 要 】

Gd2O3 nanoparticles doped with different amount of Yb3+ ions and coated with citrate molecules were prepared by a cheap and fast co-precipitation procedure and proposed as potential “positive” contrast agents in magnetic resonance imaging. The citrate was used to improve the aqueous suspension, limiting particles precipitation. The relaxometric properties of the samples were studied in aqueous solution as a function of the magnetic field strength in order to evaluate the interaction of the paramagnetic ions exposed on the surface with the water molecules in proximity. The nanoparticles showed high relaxivity values at a high magnetic field with respect to the clinically used Gd3+-chelates and comparable to those of similar nanosytems. Special attention was also addressed to the investigation of the chemical stability of the nanoparticles in biological fluid (reconstructed human serum) and in the presence of a chelating agent.

【 授权许可】

Unknown