The Risk of Malignancies in Celiac Disease—A Literature Review

Cancers

Francesco Piazza¹  Brigida Barberio²  Filippo Pelizzaro²  Ilaria Marsilio²  Anna D’Odorico²  Fabiana Zingone²  Fabio Farinati²  Edoardo V. Savarino²  Matteo Fassan³ 

[1] Department of Medicine, Hematology, University Hospital of Padova, 35128 Padova, Italy;Gastroenterology Unit, Department of Surgery, Oncology and Gastroenterology, University Hospital of Padova, 35128 Padova, Italy;Surgical Pathology and Cytopathology Unit, Department of Medicine (DIMED), University Hospital of Padova, 35128 Padova, Italy;

关键词: celiac disease;    malignancy;    complication;    tumor;    lymphoma;    carcinoma;   

DOI  :  10.3390/cancers13215288

来源: DOAJ

【 摘 要 】

Celiac disease (CeD) is an immune-mediated enteropathy precipitated by ingestion of gluten in genetically predisposed individuals. Considering that CeD affects approximately 1% of the Western population, it may be considered a global health problem. In the large majority of cases, CeD has a benign course, characterized by the complete resolution of symptoms and a normal life expectancy after the beginning of a gluten-free-diet (GFD); however, an increased risk of developing malignancies, such as lymphomas and small bowel carcinoma (SBC), has been reported. In particular, enteropathy-associated T-cell lymphoma (EATL), a peculiar type of T-cell lymphoma, is characteristically associated with CeD. Moreover, the possible association between CeD and several other malignancies has been also investigated in a considerable number of studies. In this paper, we aim to provide a comprehensive review of the current knowledge about the associations between CeD and cancer, focusing in particular on EATL and SBC, two rare but aggressive malignancies.

【 授权许可】

Unknown