Cortical Activation During Finger Tapping Task Performance in Parkinson's Disease Is Influenced by Priming Conditions: An ALE Meta-Analysis

Frontiers in Human Neuroscience

Zhongquan Du³  Xueqing Qiu³  Jingjing Li³  Ningning Zhu³  Xia Xu⁴  Zheng Liu⁵ 

[1] ANU College of Health and Medicine, Australian National University, Canberra, ACT, Australia;College of Health Science, Wuhan Sports University, Wuhan, China;Graduate School, Wuhan Sports University, Wuhan, China;Hubei Key Laboratory of Exercise Training and Monitoring, Wuhan Sports University, Wuhan, China;Sydney School of Education and Social Work, University of Sydney, Sydney, NSW, Australia;

关键词: finger tapping task;    Parkinson's disease;    motor control;    self-priming;    cue-priming;    ALE meta-analysis;   

DOI  :  10.3389/fnhum.2021.774656

来源: DOAJ

【 摘 要 】

The finger tapping task (FTT) is commonly used in the evaluation of dyskinesia among patients with Parkinson's disease (PD). Past research has indicated that cortical activation during FTT is different between self-priming and cue-priming conditions. To evaluate how priming conditions affect the distribution of brain activation and the reorganization of brain function, and to investigate the differences in brain activation areas during FTT between PD patients and healthy control (HC) participants, we conducted an activation likelihood estimation (ALE) meta-analysis on the existing literature. Analyses were based on data from 15 independent samples that included 181 participants with PD and 164 HC participants. We found that there was significantly more activation in the middle frontal gyrus, precentral gyrus, post-central gyrus, superior parietal lobe, inferior parietal lobule, cerebellum, and basal ganglia during FTT in PD patients than in HCs. In self-priming conditions, PD patients had less activation in the parietal lobe and insular cortex but more activation in the cerebellum than the HCs. In cue-priming conditions, the PD patients showed less activation in the cerebellum and frontal-parietal areas and more activation in the superior frontal gyrus and superior temporal gyrus than the HCs. Our study illustrates that cue-priming manipulations affect the distribution of activity in brain regions involved in motor control and motor performance in PD patients. In cue-priming conditions, brain activity in regions associated with perceptual processing and inhibitory control was enhanced, while sensory motor areas associated with attention and motor control were impaired.

【 授权许可】

Unknown