Movement-related coupling of human subthalamic nucleus spikes to cortical gamma

eLife

Robert S Turner¹  Wolf-Julian Neumann²  R Mark Richardson³  Pascal Fries⁴  Petra Fischer⁵  Peter Brown⁵  Witold J Lipski⁶ 

[1] Department of Neurobiology, University of Pittsburgh, Pittsburgh, United States;Center for the Neural Basis of Cognition, University of Pittsburgh, Pittsburgh, United States;Department of Neurology, Campus Mitte, Charite - Universitaetsmedizin Berlin, Berlin, Germany;Department of Neurosurgery, Massachusetts General Hospital, Boston, United States;Harvard Medical School, Boston, United States;Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, Frankfurt, Germany;Donders Institute for Brain, Cognition and Behaviour, Nijmegen, Netherlands;Medical Research Council Brain Network Dynamics Unit, University of Oxford, Oxford, United Kingdom;Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom;Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, United States;

关键词: Parkinson's disease;    subthalamic nucleus;    motor control;    gamma oscillations;    ECoG;    spike coupling;    Human;   

DOI  :  10.7554/eLife.51956

来源: publisher

【 摘 要 】

Cortico-basal ganglia interactions continuously shape the way we move. Ideas about how this circuit works are based largely on models those consider only firing rate as the mechanism of information transfer. A distinct feature of neural activity accompanying movement, however, is increased motor cortical and basal ganglia gamma synchrony. To investigate the relationship between neuronal firing in the basal ganglia and cortical gamma activity during movement, we analysed human ECoG and subthalamic nucleus (STN) unit activity during hand gripping. We found that fast reaction times were preceded by enhanced STN spike-to-cortical gamma phase coupling, indicating a role in motor preparation. Importantly, increased gamma phase coupling occurred independent of changes in mean STN firing rates, and the relative timing of STN spikes was offset by half a gamma cycle for ipsilateral vs. contralateral movements, indicating that relative spike timing is as relevant as firing rate for understanding cortico-basal ganglia information transfer.

【 授权许可】

CC BY